POC - THEORY
1) Structuress and Physical properties:
a. Polarity of bonds, polarity of molecules, M.P, Inter molecular forces, B.P, Solubility, non ionic solutes and ionic solutes, protic and ion pairs,
b. Acids and bases, Lowry bronsted theories
c. Isomerism
2. Nomenclature of organic compound belonging to the following classes Alkanes, Alkenes, Dienes, Alkynes, Alcohols, Aldehydes, Ketones, Amides, Amines, Phenols, Alkyl Halides, Carboxylic Acid, Esters, Acid Chlorides and Cycloalkanes.
3. Free radicals chain reactions of alkane : Mechanism, relative reactivity and stability.
4. Alicyclic compounds : Preparations of cyclo alk orbital picture of angle strain
5. Nuclophilic aliphatic substitution mechanism:
Nucleophiles and leaving groups, kinetics of second and first order reaction, mechanism and kinetics of SN2 reactions.
Stereochemistry and steric hindrance, role of solvents, phase transfer catalysis, mechanism and kinetics of SN1 reactions, stereochemistry, carbocation and their stability, rearrangement of carbocation, role of solvents in SN1 reaction, Ion dipole bonds, SN2 versus SN1 solvolyses nucleophilic assistance by the solvents.
6. Dehydro halogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1 mechanism, elimination via carbocation, evidence for E2 mechanism, absence of rearrangement isotope effect, absence hydrogen excha nge, the element effect, orientation and reactivity, E2 versus E1, elimination versus substitution, dehydration of alcohol, ease of dehydration, acid catalysis, reversibility, orientation.
7. Electrophillic and free radicals addition: Reactions at carbonc arbon, double bond, electrophile, hydrogenation, heat of hydrogenation and stability of alkenes, markownikoff rule, addition of hydrogen halides, addition of hydrogen bromides, peroxide effect, electrophillic addition, mechanism, rearrangement, absence of hydrogen exchange, orientation and reactivity, addition of halogen, mechanism, halohydin formation, mechanism of free radicals additon, mechanism of peroxide initiated addition of hydrogen bromide, orientation of free addition, additions of carbene to alke ne, cyclo addition reactions.
8. Carboncarbon double bond as substituents:
Free radical halogenations of alkenes, comparision of free radical substitution with free radical addition, free radical substitution in alkenes, orientation and reactivity, allyl ic rearrangements.
9. Theory of resonance:
Allyl radical as a resonance hybrid, stability, orbital picture, resonance stabilisation of allyl radicals, hyper conjugation, allyl cation as a resonance hybrid, nucleophyllic substitution in allylic substrate, SN1 reactivity, allylic rearrangement, resonance stabilisation of allyl cation, hyper conjugation, nucleophilic substitution in allylic substrate, SN2 nucleophilic substituion in vinylic substrate, vinylic cation, stability of conjugated dienes, resonance in alkenes, hyper conjugation, ease of formation of conjugated dienes, orientation of elimination, electrophilic addition to conjugated dienes, 1-4 addition ,1-2 versus 1-4 addition, rate v/s equilibrium, orientation and reactivity of free radical . Addition to congugated dienes.
10. Elecrophilic aromatic substitution: Effect of substituent groups, determination of orientation, determination of relative reactivity, classification of substituent group, mechanism of nitration, sulphonation, halogenation, friedel craft alkylation, friedel craft acylation, reactivity and orientation, activating and deactivating O,P,M directing groups, electron release via resonance, effect of halogen on electrophilic aromatic substitution in alkyl benzene, side chain halogi nation of alkyl benzene, resonance stabilization of benzyl radical.
11. Nucleophilic addition reaction: Mechanism, ionisation of carboxylic acids, acidity constants, acidity of acids, structure of carboxylate ions, effect of substituent on acidity, nucleop hilic acyl substitution reaction, conversion of acid to acid chloride, esters, amide and anhydride. Role of caboxyl group, comparison of alkyl nucleophilic substitution with acyl nucleophilic substitution
12. Mechanism of aldol condensation, claisen condensation, cannizzaro reaction, crossed aldol condensation, crossed cannizzaro reaction, benzoin condensation, perkin condensation. Knoevenagel, Reformatsky reaction, Wittig reaction, Michael addition.
13 Hoffman rearrangement: Migration to electrreaction, basicity of amines, diazotisation and coupling, acidity of phenols, reactions.
14 Nucleophilic aromatic substitution: Bimolecular displacement mechanisms, orientation, comparison of aliphatic nucleophilic substitution with that of aromatic.
15 Oxidation reduction reaction.
16. Study of the following official compounds- preparation, test for purity, assay and medicinal uses of Chlorbutol, Dimercaprol, Glyceryl trinitrate, Urea, Ethylene diamine dihyrate, Vanillin, Paraldehyde, Ethylene chloride, Lactic acid, Tartaric acid, citric acid, salicylic acid, aspirin, methyl salicylate, ethyl benzoate, benzyl benzoate, dimethyl pthalate, sodium lauryl sulphate, saccharin sodium, mephensin
POC - PRACTICAL
Introduction to the various laboratory techniques through demonstration involving synthesis of the following compounds (at least 8 compounds to be synthesised):
1. Acetanilde / aspirin (Acetylation)
2. Benzanilide / Phenyl benzoate (Benzoylation)
3. P-bromo acetanilide / 2,4,6 tribromo aniline (Bromination)
4. Dibenzylidene acetone (Condensation)
5. 1-Phenylazo-2-napthol (Diazotisation and coupling)
6. Benzoic acid / salicylic acid (Hydrolysis of ester)
7. M-dinitro benzene (Nitration)
8. 9, 10 Antharaquinone (Oxidation of anthracene) / preparation of benzoic acid from toluene or benzaldehyde
9. M-phenylene diamine (Reduction of M-dinitrobenzene) / Aniline from nitrobenzene
10. Benzophenone oxime
11. Nitration of salicylic acid
12. Preparation of picric acid
13. Preparation of O-chlorobenzoic acid from O-chlorotolune
14. Preparation of cyclohexanone from cyclohexanol
II. Identification of organic compounds belonging to the following classes by :
Systematic qualitative organic analysis including preparation of derivatives Phenols, amides, carbohydrates, amines, carboxylic acids, aldehyde and ketones, Alcohols, esters, hydrocarbons, anilides, nitrocompounds.
III. Introduction to the use of stereo models: Methane, Ethane, Ethylene, Acetylene, Cis alkene, Trans alkene, inversion of configuration
1) Structuress and Physical properties:
a. Polarity of bonds, polarity of molecules, M.P, Inter molecular forces, B.P, Solubility, non ionic solutes and ionic solutes, protic and ion pairs,
b. Acids and bases, Lowry bronsted theories
c. Isomerism
2. Nomenclature of organic compound belonging to the following classes Alkanes, Alkenes, Dienes, Alkynes, Alcohols, Aldehydes, Ketones, Amides, Amines, Phenols, Alkyl Halides, Carboxylic Acid, Esters, Acid Chlorides and Cycloalkanes.
3. Free radicals chain reactions of alkane : Mechanism, relative reactivity and stability.
4. Alicyclic compounds : Preparations of cyclo alk orbital picture of angle strain
5. Nuclophilic aliphatic substitution mechanism:
Nucleophiles and leaving groups, kinetics of second and first order reaction, mechanism and kinetics of SN2 reactions.
Stereochemistry and steric hindrance, role of solvents, phase transfer catalysis, mechanism and kinetics of SN1 reactions, stereochemistry, carbocation and their stability, rearrangement of carbocation, role of solvents in SN1 reaction, Ion dipole bonds, SN2 versus SN1 solvolyses nucleophilic assistance by the solvents.
6. Dehydro halogenation of alkyl halides: 1,2 elimination, kinetics, E2 and E1 mechanism, elimination via carbocation, evidence for E2 mechanism, absence of rearrangement isotope effect, absence hydrogen excha nge, the element effect, orientation and reactivity, E2 versus E1, elimination versus substitution, dehydration of alcohol, ease of dehydration, acid catalysis, reversibility, orientation.
7. Electrophillic and free radicals addition: Reactions at carbonc arbon, double bond, electrophile, hydrogenation, heat of hydrogenation and stability of alkenes, markownikoff rule, addition of hydrogen halides, addition of hydrogen bromides, peroxide effect, electrophillic addition, mechanism, rearrangement, absence of hydrogen exchange, orientation and reactivity, addition of halogen, mechanism, halohydin formation, mechanism of free radicals additon, mechanism of peroxide initiated addition of hydrogen bromide, orientation of free addition, additions of carbene to alke ne, cyclo addition reactions.
8. Carboncarbon double bond as substituents:
Free radical halogenations of alkenes, comparision of free radical substitution with free radical addition, free radical substitution in alkenes, orientation and reactivity, allyl ic rearrangements.
9. Theory of resonance:
Allyl radical as a resonance hybrid, stability, orbital picture, resonance stabilisation of allyl radicals, hyper conjugation, allyl cation as a resonance hybrid, nucleophyllic substitution in allylic substrate, SN1 reactivity, allylic rearrangement, resonance stabilisation of allyl cation, hyper conjugation, nucleophilic substitution in allylic substrate, SN2 nucleophilic substituion in vinylic substrate, vinylic cation, stability of conjugated dienes, resonance in alkenes, hyper conjugation, ease of formation of conjugated dienes, orientation of elimination, electrophilic addition to conjugated dienes, 1-4 addition ,1-2 versus 1-4 addition, rate v/s equilibrium, orientation and reactivity of free radical . Addition to congugated dienes.
10. Elecrophilic aromatic substitution: Effect of substituent groups, determination of orientation, determination of relative reactivity, classification of substituent group, mechanism of nitration, sulphonation, halogenation, friedel craft alkylation, friedel craft acylation, reactivity and orientation, activating and deactivating O,P,M directing groups, electron release via resonance, effect of halogen on electrophilic aromatic substitution in alkyl benzene, side chain halogi nation of alkyl benzene, resonance stabilization of benzyl radical.
11. Nucleophilic addition reaction: Mechanism, ionisation of carboxylic acids, acidity constants, acidity of acids, structure of carboxylate ions, effect of substituent on acidity, nucleop hilic acyl substitution reaction, conversion of acid to acid chloride, esters, amide and anhydride. Role of caboxyl group, comparison of alkyl nucleophilic substitution with acyl nucleophilic substitution
12. Mechanism of aldol condensation, claisen condensation, cannizzaro reaction, crossed aldol condensation, crossed cannizzaro reaction, benzoin condensation, perkin condensation. Knoevenagel, Reformatsky reaction, Wittig reaction, Michael addition.
13 Hoffman rearrangement: Migration to electrreaction, basicity of amines, diazotisation and coupling, acidity of phenols, reactions.
14 Nucleophilic aromatic substitution: Bimolecular displacement mechanisms, orientation, comparison of aliphatic nucleophilic substitution with that of aromatic.
15 Oxidation reduction reaction.
16. Study of the following official compounds- preparation, test for purity, assay and medicinal uses of Chlorbutol, Dimercaprol, Glyceryl trinitrate, Urea, Ethylene diamine dihyrate, Vanillin, Paraldehyde, Ethylene chloride, Lactic acid, Tartaric acid, citric acid, salicylic acid, aspirin, methyl salicylate, ethyl benzoate, benzyl benzoate, dimethyl pthalate, sodium lauryl sulphate, saccharin sodium, mephensin
POC - PRACTICAL
Introduction to the various laboratory techniques through demonstration involving synthesis of the following compounds (at least 8 compounds to be synthesised):
1. Acetanilde / aspirin (Acetylation)
2. Benzanilide / Phenyl benzoate (Benzoylation)
3. P-bromo acetanilide / 2,4,6 tribromo aniline (Bromination)
4. Dibenzylidene acetone (Condensation)
5. 1-Phenylazo-2-napthol (Diazotisation and coupling)
6. Benzoic acid / salicylic acid (Hydrolysis of ester)
7. M-dinitro benzene (Nitration)
8. 9, 10 Antharaquinone (Oxidation of anthracene) / preparation of benzoic acid from toluene or benzaldehyde
9. M-phenylene diamine (Reduction of M-dinitrobenzene) / Aniline from nitrobenzene
10. Benzophenone oxime
11. Nitration of salicylic acid
12. Preparation of picric acid
13. Preparation of O-chlorobenzoic acid from O-chlorotolune
14. Preparation of cyclohexanone from cyclohexanol
II. Identification of organic compounds belonging to the following classes by :
Systematic qualitative organic analysis including preparation of derivatives Phenols, amides, carbohydrates, amines, carboxylic acids, aldehyde and ketones, Alcohols, esters, hydrocarbons, anilides, nitrocompounds.
III. Introduction to the use of stereo models: Methane, Ethane, Ethylene, Acetylene, Cis alkene, Trans alkene, inversion of configuration
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